COVID infections in animals - a key to the ongoing trajectory of the pandemic?
The COVID-19 pandemic was probably caused by the transmission of the SARS-CoV-2 virus from animals to humans, and it has been reported anecdotally that the virus can pass from humans to different animal species, too. To find out how the transmission of the virus between humans and animals affects its ability to infect and cause disease in humans an international team led by 不良研究所 researchers has begun of inter-species transmission. By doing so, the researchers hope to gain insight into the likely ongoing trajectory of the virus.听
Their goal was to discover both the rates of transmission, and whether there were specific viral mutations that occurred frequently enough to suggest they were helping the virus adapt to a particular animal. Transmission of the virus in different non-human animals, such as mink and deer, could put the virus on different evolutionary trajectories that could affect its ability to infect and cause disease in humans鈥攅ither in a positive or negative way.听
Humans transmit COVID virus to animals more frequently than vice versa听
The researchers carried out statistical analyses based on all the available viral genome sequence data from four different animal species.听
鈥淲e found that humans transmitted the virus to cats, dogs, minks, and deer dozens of times,鈥� said Jesse Shapiro, an associate professor in 不良研究所鈥檚 Department of Microbiology and Immunology and the senior author on a paper that was recently published in . 鈥淏ut transmission from these animals back to humans is rarely observed鈥攅xcept for minks, which transmitted the virus back to humans on dozens of separate occasions.鈥澨�
Mutations of virus in mink and deer associated with COVID infections听
The researchers identified just three mutations, all in the viral spike protein, which are most likely to help the virus adapt to infecting and transmitting in mink. They also found several mutations, many of which had not been previously reported, that were significantly associated with SARS-CoV-2 infections in deer.听
鈥淥ther recent studies have found that SARS-CoV-2 evolves particularly rapidly in deer, consistent with our discovery of a relatively large number of deer-associated mutations,鈥� said Sana Naderi, the first author on the paper and a graduate student at 不良研究所. 鈥淲hile many of these mutations are likely to help the virus replicate in deer, it remains to be seen if they make the virus more or less likely to infect humans.鈥澨�
A need for further sampling and more lab work听
The researchers hope that their results will spur greater sampling of SARS-CoV-2 from different animal species鈥攊ncluding more poorly sampled species such as cats and dogs, as well as further sampling from both deer and mink which could be important reservoirs of genetic diversity for the virus. They suggest that these mutations could also be studied in lab experiments to determine if, and under what conditions, they affect replication and transmission of the virus鈥攁nd, importantly, if their adaptation to one animal species comes with a trade off in terms of reduced adaptation to humans (or not).听
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About the study听
鈥溾�� by Sana Naderi, Peter E Chen, Carmen Lia Murall, Raphael Poujol, Susanne Kraemer, Bradley S Pickering, Selena M Sagan, and Jesse Shapiro was published in eLife.听
