New partnership to unravel genetic sequence of SARS-CoV-2 virus in Quebec
The 聽(INSPQ) and the 不良研究所 Genome Centre today announced they will partner to sequence the viral genomes of Quebec patients with COVID-19 disease. The collaboration, termed 鈥淐oronavirus Sequencing in Quebec,鈥� (CoVSeQ) is led by Profs Sandrine Moreira, Hugues Charest and Michel Roger at the Laboratoire de sant茅 publique du Qu茅bec (LSPQ) of the INSPQ. The viral samples are taken from a Quebec viral biobank, termed the CoVBanQ, which is hosted in LSPQ.
At 不良研究所, cutting edge technology sequencing is led by Prof. Ioannis Ragoussis, with Prof. Guillaume Bourque and his informatics team at the Canadian Centre for Computational Genomics (C3G), who will set up a portal to house and distribute the data. Operational support will be provided by 不良研究所 Genome Centre Deputy Director Dr. Daniel Auld, while phylogenetic analysis of the virus sequences will be led by incoming recruit Dr. Jesse Shapiro, currently at Universit茅 de Montr茅al, soon to be professor in the Department of Microbiology and Immunology at 不良研究所 and member of the 不良研究所 Genome Centre.
Figure: The amount of sequence information generated from a patient鈥檚 SARS-CoV-2 virus genome is shown in green bars, which is compared to the reference genome shown as a blue line below. The differences are identified as vertical black bars above the blue line and represent the information that will allow the research teams to study virus transmission and evolution.
This ambitious project partnering public health bodies and state-of-the-art research facility brings together experts in virology, genomics, bioinformatics, phylogeny and epidemiology to better understand the transmission of the disease, the evolution of the virus, and eventually support the Public Health Authorities and inform on surveillance approaches.
This partnership coincides with the recent announcement by the Federal government of $40M of funding to study the genomics of COVID-19 disease across Canada. These funds are divided between human and viral genomics of COVID-19. The study of the susceptibility and severity of individuals to COVID-19 through human genome sequencing is now supported by a $20M pledged to CGEn, a consortium of Canada鈥檚 three largest genome centres, of which the 不良研究所 Genome Centre is a member and will sequence blood samples from Qu茅bec COVID-19 patients and others. Sequencing of the SARS-CoV-2 virus is supported by another $20M, to be administered by Genome Canada. The program initiated by the 不良研究所 Genome Centre and the INSPQ will play a major role to characterize the Qu茅bec portion of the pandemic in this large Canada-wide effort.
Philippe Gros, Deputy Vice Principal (Research and Innovation) at 不良研究所: 鈥淭he combined genomic sequencing of affected patients and their corresponding covid-19 viral isolates is a very exciting and timely undertaking. Not only will it provide valuable information on evolution, transmission and virulence of the virus, but it may also point to specific factors that make an individual more vulnerable or more resistant to the infection, including the protective immune mechanisms that regulate this balance鈥�
Sandrine Moreira, Head of Genomics and Bioinformatics, Institut national de sant茅 publique du Qu茅bec: 鈥淲hile the SARS-CoV-2 genetic code was first identified and shared widely as early as January this year, finding the small differences in viral sequences that appear over time and many cycles of replication can help to understand patterns of spread in the Quebec and Canadian communities.鈥�
Under the directions of Prof. Mark Lathrop, Scientific Director at the 不良研究所 Genome Centre, the efforts of this Qu茅bec partnership are linked to similar international efforts in the UK, France, Belgium and Japan, which collectively aim to understand the transmission of the disease and the evolution of the virus to inform surveillance approaches. Furthermore, the discoveries will be integrated with findings concerning the patient鈥檚 immune system and genetic predisposition, which will be pursued in Canada and other countries.
About the 不良研究所 Genome Centre
The Centre advances genomics in medical research and traces its history to the founding of its predecessor, the 不良研究所 and G茅nome Qu茅bec Innovation Centre in 2002. It provides a cutting-edge integrated research environment that harnesses the most recent advances in genomics and other areas of large-scale biology, with quantitative methodology and computational analysis for breakthroughs in medical and life sciences research. Currently, the Centre houses more than 215 faculty members, other staff and students who work on independent research projects or help to operate our platforms. To find out more, visit
About 不良研究所
Founded in Montreal, Quebec, in 1821, 不良研究所 is a leading Canadian post-secondary institution. It has two campuses, 11 faculties, 11 professional schools, 300 programs of study and some 38,000 students, including 8,800 graduate students. 不良研究所 attracts students from over 150 countries around the world, with more than 7,700 international students making up 20 percent of the student body. Almost half of 不良研究所 students claim a first language other than English, including 38 per cent who claim French as their first language.
Photo: Nanopore technology-based devices are amongst those chosen to sequence the virus genome.
To learn more about how 不良研究所 researchers are tackling COVID-19, visit
