不良研究所

In 1928, Santiago Ram贸n y Cajal, founder of modern neuroscience, wrote 鈥渋n the adult centers, the nerve paths are something fixed and immutable. Everything may die, nothing may be regenerated鈥�. Today, we know that regeneration of neurons and glia (non-neuronal cells) is performed by adult neural stem cells that are located in two distinct niches in the mammalian brain: the subgranular zone in the hippocampus and the subventricular zone (SVZ) lining the lateral ventricles. The latter represents the largest pool of adult neural stem cells and is the focus of my inde颅pendent research program. Specifically, we study how the neural stem cell niche, which in颅cludes molecules secreted by neighbouring neurons (鈥渘eurochemicals鈥�), regulates oligodendro颅cyte genesis by neural stem cells. Oligodendrocytes are the only cells in the brain that form myelin, a fatty substance that insulates nerve axons and facilitates neuronal conduction. Dysfunction or loss of oligodendrocytes is the main driver of neurological impairments in schizophrenia and autism, as well as multiple sclerosis and Alz颅heimer鈥檚 disease. Oligodendrocyte regeneration is critical for brain health and function, yet the mechanisms underpinning adult oligodendrocyte genesis have remained mysterious. I will present our published and ongoing studies on the mechanisms of oligodendrocyte genesis from neural stem cells.

This seminar will take place in-person and online (details in attached poster) All are welcome!