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Genomics and Epigenomics. The 3 billion nucleotides that make up our genome can be sequentially decoded to create a complex organism starting from a single cell. During differentiation, tissues acquire specific cell fates that are largely mediated by epigenetic modifications – DNA and chromatin changes. When disrupted, epigenetic defects result in abnormal development and cancer. We use high throughput genomics approaches, such as DNA, RNA, methylome, and ChIP-seq, to understand both normal and cancer processes. The focus of the lab is on computational analysis, but we actively collaborate with a number of laboratory scientists and clinicians.