Mark Basik
Professor
MDCM
Breast cancer
Dr. Mark Basik was born in Montreal, graduated in medicine from 不良研究所, completed a general Surgery Residency at the Universit茅 de Montreal, followed by a fellowship in Surgical Oncology at Roswell Park Cancer Institute. He was a visiting investigator at the National Institutes of Health in Bethesda. He returned to Montreal in 2003, where he is now practicing breast cancer surgery at the Jewish General Hospital in Montreal, QC, and he is the Herbert Black professor of Surgical Oncology at 不良研究所. He heads the Cancer Genomics and Translational Research Laboratory at the Lady Davis Institute for Medical Research. His research interests include understanding the causes of resistance to therapy in breast cancer as well as developing new diagnostic blood tests involving circulating tumor DNA for breast cancer. He co-leads the Molecular Tumor Board at the Jewish General Hospital since 2018.
1.Aguilar-Mahecha A, Alirezaie N, Lafleur J, Bareke E, Przybytkowski E, Lan C, Cavallone L, Salem M, Pelmus M, Aleynikova O, Greenwood C, Lovato A, Ferrario C, Boileau JF, Mihalcioiu C, Roy JA, Marcus E, Discepola F, Majewski J, Basik M. The Mutational Spectrum of Pre- and Post-Neoadjuvant Chemotherapy Triple-Negative Breast Cancers. Genes (Basel). 2023 Dec 23;15(1):27. doi: 10.3390/genes15010027.PMID: 38254917
2.Aguilar-Mahecha A, Lafleur J, Brousse S, Savichtcheva O, Holden KA, Faulkner N, McLennan G, Jensen TJ, Basik M. Early, On-Treatment Levels and Dynamic Changes of Genomic Instability in Circulating Tumor DNA Predict Response to Treatment and Outcome in Metastatic Breast Cancer Patients. Cancers (Basel). 2021 Mar 16;13(6):1331.
3.Cavallone L, Aguilar-Mahecha A, Lafleur J, Brousse S, Aldamry M, Roseshter T, Lan C, Alirezaie N, Bareke E, Majewski J, Ferrario C, Hassan S, Discepola F, Seguin C, Mihalcioiu C, Marcus EA, Robidoux A, Roy JA, Pelmus M, Basik M. Prognostic and predictive value of circulating tumor DNA during neoadjuvant chemotherapy for triple negative breast cancer. Sci Rep. 2020 Sep 7;10(1):14704.
4. Sirois I, Aguilar-Mahecha A, Lafleur J, Fowler E, Vu V, Scriver M, Buchanan M, Chabot C, Ramanathan A, Balachandran B, L茅gar茅 S, Przybytkowski E, Lan C, Krzemien U, Cavallone L, Aleynikova O, Ferrario C, Guilbert MC, Benlimame N, Saad A, Alaoui-Jamali M, Saragovi HU, Josephy S, O'Flanagan C, Hursting SD, Richard VR, Zahedi RP, Borchers CH, Bareke E, Nabavi S, Tonellato P, Roy JA, Robidoux A, Marcus EA, Mihalcioiu C, Majewski J, Basik M. A Unique Morphological Phenotype in Chemoresistant Triple-Negative Breast Cancer Reveals Metabolic Reprogramming and PLIN4 Expression as a Molecular Vulnerability. Mol Cancer Res. 2019 Dec;17(12):2492-2507.
