Brain diseases are the leading cause of disability in Canadians with more than 3.6 million Canadians affected by a brain condition. With an aging population, new treatments are desperately needed.
Two of the world鈥檚 most accomplished neuroscience research initiatives at 不良研究所 and Western University have combined their expertise to convert scientific research to societal impact.
The 不良研究所-Western Initiative for Translational Neuroscience (ITN) brings together world-renowned scientists to work on five large-scale research projects focusing on biotherapeutics, epilepsy, ALS and Parkinson鈥檚 Disease. This collaborative work will have immediate impact for patients living with brain diseases and disorders in Canada and around the world.
The ITN is supported by the Canada First Research Excellence Fund (CFREF) through Healthy Brains, Healthy Lives and initiatives.
ITN Scientific Directors
- Dr. Alan Evans, PhD, FRSC (不良研究所)
- Dr. Ravi Menon, PhD, FCAHS, FRSC (Western)
- Dr. Lisa Saksida, PhD, FCAHS, FRSC (Western)
Funded Projects
Translating epilepsy neuroimaging biomarkers into the operating room
This project aims to improve epilepsy surgery by translating advanced MRI biomarkers into the operating room for patients with drug-resistant epilepsy. Using high- and ultra-high field neuroimaging at 不良研究所 and Western, the team will create personalized brain maps and identify surgical targets. By integrating these maps into surgical navigation tools, this innovative neuroinformatics workflow seeks to provide a more precise and personalized approach, potentially improving seizure control and the overall well-being of patients.听
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Boris Bernhardt, 不良研究所 (left); Jonathan Lau, Western University (right)
Project start date:听March 1, 2024
Project end date: February 28, 2026
Total HBHL contribution: $291,500
Total BrainsCAN contribution: $261,500
Non-invasive neurostimulation guided by circuit models for suppressing epileptiform activity
This project aims to explore the use of transcranial electrical stimulation (tES), a non-invasive method that modulates cortical circuits, as a potential treatment for suppressing epileptiform activity in patients with drug-resistant epilepsy. By combining insights from recent studies on the effects of tES on neural spiking activity (Pack) and computational models of brain activity patterns (Muller), this project aims to develop a novel technology that could significantly impact clinical practices in epilepsy treatment within the next few years, avoiding the need for invasive brain surgery.听
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Christopher Pack, 不良研究所 (left); Lyle Muller, Western University (right)
Project start date: March 1, 2024
Project end date:听February 28, 2025
Total HBHL contribution: $189,153
Total BrainsCAN contribution: $80,000
Impaired tRNA Function in Amyotrophic Lateral Sclerosis (ALS)
ALS (amyotrophic lateral sclerosis) is a fatal neurodegenerative disease with limited treatment options. This project focuses on the role of transfer RNAs (tRNAs) in ALS, small molecules that play a crucial role in cellular function. By studying impaired tRNA function in ALS, the project aims to identify genetic factors increasing the risk of developing the disease. This research will translate into a novel assessment tool for ALS risk and serve as a biomarker to evaluate potential treatments.听The methodologies developed can also be applied to other neurodegenerative diseases like Alzheimer's and Parkinson's.听
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From the left: Sali Farhan, 不良研究所; Thomas Durcan, 不良研究所; Martin Duennwald, Western University
Project start date: January 1, 2024
Project end date: December 31, 2025
Total HBHL contribution:听$400,000
Total BrainsCAN contribution: $255,000
Early biomarkers for development and monitoring of effective disease-modifying therapies
In this project, the collaborative team will develop a platform for early drug evaluation that focuses on unique imaging and cognitive biomarkers. Using a platform that works in the preclinical phase, this method will increase the likelihood that early findings will translate to the clinic. These biomarkers will also help identify patients who may benefit most from specific types of drugs.
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Mallar Chakravarty, 不良研究所 (left); Marco Prado, Western University (right)
Project start date: April 1, 2022
Project end date: March 31, 2025
Total HBHL contribution:听$1,722,000
Total BrainsCAN contribution: $2,034,000
Early biomarkers to improve diagnostic workup in Parkinson's Disease
To better understand the areas of the brain most affected by Parkinson鈥檚 Disease, this project will use magnetic resonance imaging (MRI) to identify the disease's biomarkers. These biomarkers will help to better diagnose Parkinson鈥檚, reduce a patient鈥檚 wait time for a diagnosis and make it easier to measure the disease鈥檚 progression.
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Alain Dagher, 不良研究所 (left); Penny MacDonald, Western University (right)
Project start date: April 1, 2022
Project end date: August 17, 2023
Total HBHL contribution:听$426,000
Total BrainsCAN contribution: $322,000
