不良研究所

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• Principal Investigator, Zandee Lab
• Scientist, Research Institute of the 不良研究所 Health Centre
• Assistant Professor, Integrated Program in Neuroscience
• Researcher, Montreal Neurological Institute-Hospital, Department of Neurology and Neurosurgery
• Principal Investigator - Ludmer Centre for Neuroinformatics and Mental Health

Stephanie Zandee, PhD, joined 不良研究所 in 2024, where she will be an Assistant Professor in the Integrated Program in Neuroscience, and the Principal Investigator of the Zandee Lab. Prior to joining 不良研究所, she completed a postdoctoral fellowship at the Centre de Recherche du CHUM (Universit茅 de Montr茅al), where she was also leading the Prat lab MS and amyotrophic lateral sclerosis (ALS) brain bank and rapid autopsy program. .

Located in the Montreal Neurological Institute, the Zandee lab has the goal of understanding multiple sclerosis (MS) brain lesion evolution (formation, destruction, repair) at the transcriptomic and proteomic level using single cell approaches and machine learning (ML) methods. To achieve this, Prof. Zandee is using fluorescent imaging in conjunction with single-cell and bulk RNA-sequencing, tissue clearing with light sheet microscopy plus machine learning on images to discover patterns in lesions. A specific interest of the lab is understanding the role of the novel anti-inflammatory cytokine IL-37 in human brain homeostasis and inflammation in the context of MS. To achieve this, the Zandee lab is using human MS brain tissue, mouse models of MS (called experimental autoimmune encephalomyelitis; EAE), confocal microscopy, cell culture of human primary brain cells and flow cytometry on rapid autopsy brain tissue.

• Visit for a list of publications.

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