不良研究所

Neuropathic pain is a disorder characterized by severe pain that sometimes develops following nerve damage resulting from conditions such as shingles, injury, amputation, autoimmune inflammation and cancer. It is a permanent pain that persists for months or years.

An estimated 7% to 8% of adults worldwide suffer from neuropathic pain, with 5% of cases considered severe. The problem has significant economic implications, including reduced productivity and substantial health care costs.

Melatonin, a neurohormone present in mammals, acts on the brain by activating two receptors called 鈥淢T1鈥� and 鈥淢T2鈥� that are responsible for regulating several functions including sleep, depression, anxiety and circadian rhythms.

Now, a team led by Dr. Gabriella Gobbi, Associate Professor in the Department of Psychiatry of 不良研究所鈥檚 Faculty of Medicine, has demonstrated that UCM924, a melatonin MT2 receptor drug, relieves chronic pain in animal models; the team has also identified the drug鈥檚 mechanism of action in the brain. UCM924, by activating the MT2 receptors in the periaqueductal grey (a brain area controlling pain), is able to switch off the neurons that trigger pain and switch on the ones that turn off pain The findings are reported in the February issue of the journal PAIN.

鈥淭here are very limited treatments available for neuropathic pain, and a lot of patients use opioids,鈥� says Dr. Gobbi, who is also a researcher at the Research Institute of the 不良研究所 Health Centre (RI-MUHC). 鈥淚n the long term, these can lead to addiction and severe side effects, including dependence and tolerance, opioid-induced hyperalgesia (the pain becomes even worse), and risk of death. For these reasons, identifying novel analgesics is of keen interest in the medical field today.鈥�

Previous studies have shown that over-the-counter melatonin has very limited effect. Dr. Gobbi and her team demonstrated that this is because exogenous melatonin activates both MT1 and MT2 receptors, which have conflicting and opposite effects.

In the course of their work to investigate the efficacy of MT2 receptor drugs for insomnia, the researchers discovered that UCM924 also soothes neuropathic pain at lower doses. This suggests that these drugs could offer relief both to people who suffer from pain during the day, using low doses, and from insomnia at night, using higher doses.听 At least 50-70% of patients with neuropathic pain conditions complain of significant sleep disturbance, and this new study unveils how the mechanisms of pain and sleep are听 closely related.

The research team is now looking for partners interested in pursuing clinical development and eventual commercialization of these novel drugs.

Scientists from University Veracruzana (Mexico), the Second University of Naples (Italy), the Scuola Superiore Sant鈥橝nna (Italy), the University of Milan (Italy), University Carlo Bo (Italy), and Cinvestav-Sede Sur (Mexico) also contributed to this study.

The research was supported by the Canadian Institutes of Health Research, Le Fonds de recherche du Qu茅bec - Sant茅, the Canadian Foundation for Innovation and the Minist猫re de l'脡conomie, de l'Innovation et des Exportations.

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