不良研究所
The trauma division is a discrete entity with protected operating time and clinic space. Currently there are 6 trauma days per week at the Montreal General Hospital. 1200-1500 trauma acute cases are operated on per year. The trauma faculty also have a second subspecialty practice for which they have 1-2 extra operating days per week. This represents another 1000 cases per year within the trauma division. Many of these cases are tertiary care level trauma-related reconstructions.
Drs Harvey and Henderson have a laboratory on campus in the bone and periodontal research laboratory (located in the 不良研究所 Genomics center). This research is centered on fracture healing and augmentation. A multidisciplinary team from nanoengineering, cell biologists and mechanical engineers allows a comprehensive approach to fracture healing, implant design and cell modification in order to identify and market novel orthopaedic technology. Access to Instron mechano-hydraulic testing apparatus and micro CT as well as other tools facilitates the research process. (Examples- Chitosan Gene Delivery for Fracture Healing Augmentation - FGF-18 Use for Fracture Defects - Regulation of stem cell commitment to osteogenesis)
Basic Science Collaboration:
The trauma division has access and relationships with several laboratories on campus and in the MUHC research institute. Dr Seguin鈥檚 work on AVN has gathered interested followers with major funding for the lab. Thomas Steffen operates the Orthopaedic Research Lab that has an interest in biomechanical work (spine and trauma) and has technical support and engineering expertise that facilitates biomechanical research. (Examples- New Insights in the Pathogenesis of Glucocorticoid-Induced Avascular Necrosis: Microarray Analysis of Gene Expression in a Rat Model.Arthritis Research & Therapy, 2010 Jun 25;12(3):R124.; Global patterns of cis-variation in human cells revealed by high-density allelic expression analysis鈥 Nature Genetics 2009 Nov; 41 (11): 1216-22.; Magnesium-sputtered titanium for the formation of bioactive coatings鈥 Acta Biomaterialia 2009 Jul; 5 (6): 2338-47.)
Epidemiology
Clinical outcomes research is performed with a transdisciplinary group.
Faculty
Dr. Mitchell Bernstein
Appointments at:听Montreal General Hospital, Montreal Children's Hospital, Shriners Hospitals for Children
Fellowship training: Trauma /听Limb-Lengthening
Dr. Greg K. Berry
Appointments at: Montreal General Hospital
Fellowship training: Trauma / Foot and Ankle
Dr. Edward J. Harvey
Appointments at: Montreal General Hospital
Fellowship training: Trauma / Upper Extremity
Dr. Rudy Reindl
Appointments at: Montreal General Hospital
Fellowship training: Trauma / Spine
Dr. Max Talbot
Appointments at: Montreal General Hospital
Fellowship training: Trauma / Epidemiology / Military Medicine听
Affiliated Trauma Faculty
Dr. Peter Jarzem
Dr. Paul A. Martineau
Dr. Jean A. Ouellet
Current Research Staff
Janet E Henderson (PhD), Professor Medicine & Surgery,
Director Orthopaedic Research, 不良研究所
Site Coordinator, Research Institute-MUHC
Montreal General Hospital, Room A5.169
1650 Cedar Ave, Montreal H3G 1A4
Tel: 514 934-1934 ext. 43358
Affiliated Research Staff
Dr. Suzanne Morin
Dr.听Chantal Seguin
Research Students
Bouzinae Azeddine, Ph.D - Postdoctoral Fellow
JTN Wong Laboratory
740 Docteur Penfield Av, Room 2300
Montreal, Qc H3A 1A4
Chan (Fred) Gao MD- PhD Candidate
Postdoctoral Fellow
JTN Wong Laboratory
740 Docteur Penfield Av, Room 2300
Montreal, Qc H3A 1A4
Masters Students
Alberto Carli MD
Feras Waly MD
Brad Sullivan HBSc
Saad Al Qahtani MBBS
Khalid Alsheikh MBBS听
Recent Students
Justin Drager HBSc
Bogdan Matache
不良研究所 Skeletal Health Outcomes Group
Researchers
Core group
Suzanne Morin MD
Marie Hudson MD
Ed Harvey MD MSc
Rudy Reindl MD
Greg Berry MD
Pure Basic Research
Osteoporotic fracture healing model 鈥
Adjuvant healing therapies for osteoporosis: Harvey, Henderson
Bench to the Bedside Research
Hip fracture: Steffen, Ortho group (Reindl, Berry, Harvey)
Bone microarchitecture relationship to hip fractures: Kremer, Ortho group
Epithelial cell involvement in bone disease: Seguin, Harvey
Clinical Research 鈥–omparison of Hip Fracture Fixation (Canadian multicenter): Ortho group, epidemiology group
Comparison of distal radius fracture devices: Ortho group, epidemiology group
Osteoporosis studies: Morin, Hudson
Geriatric Spine Outcomes: Ouellet, Reindl, Epidemiology group
Proximal humerus fixation in osteoporotic bone: Ortho group, Steffen
Epi-Database Tools (real time online dbase studies): Epidemiology group, Spine (Ouellet, Reindl), Ortho group
Arthroplasty devices: Harvey
Education
Education processes in orthopedics and trauma are being investigated.
Examples- Investigation of a tool to teach biomechanical principles about the hip
Current Multi Centre Projects in Trauma Group
Multicenter Clinical Trials Based in 不良研究所 Trauma Group 鈥―istal Radius ORIF versus Ex Fix versus Kapandji Techniques
MultiCenter Trials Participation 鈥‵ixation Devices for Distal Femur Fractures
Clavicle Fractures- ORIF versus Conservative Management
FLOW study for Open Fractures
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