不良研究所

• Department of Chemistry
• Otto Maass Chemistry Building
• 801 Sherbrooke Street West
• Montreal QC H3A 0B8
• Canada
• Telephone: 514-398-6999
• Fax: 514-398-3797
• Email: graduate.chemistry [at] mcgill.ca
• Website: www.mcgill.ca/chemistry

Research in Chemistry

Members of the Department are organized into various research themes. Some of the current research interests are listed below, and are presented in much more detail on the Departmental website.

Analytical/Environmental

The Analytical/Environmental Thematic Research Group at 不良研究所 is involved in a wide range of exciting fundamental and applied research with focus on: state-of-the-art instrumental development in spectroscopy; imaging; chemometric and analytical bio-spectroscopy; artificial intelligence; ultra trace sampling; state-of-the-art atmospheric kinetics and photochemistry; thermochemical, box, and cloud modelling; as well as the development and application of state-of-the-art numerical models of the chemistry of the regional and global atmosphere. Our collective research has direct implications in fields such as materials, environmental, and biomedical chemistry.

Chemical Biology

The Chemical Biology Thematic Research Group is engaged in a diverse range of research topics, which span structural biology, enzymology, nucleic acid research, signalling pathways, single-molecule biophysics, and biophysical chemistry of living tissues. Among the themes that unite the research being performed in this group is the attempt to learn new chemistry and physics from biological systems.

We have projects relating to pharmaceutically relevant enzymes such as those involved in drug metabolism and antibiotic resistance; development of therapeutic agents in the control of inflammation, cancer and viral infections; the chemical biology of NO; quantification of bioenergetic markers of metabolism; self-assembly mechanisms of the HIV-1 virion capsid; liposome microarray systems to address membrane protein dynamics and recognition; studies on reactive oxygen species translocation across the aqueous/lipid membrane interface; RNAi/antisense technologies; dynamic combinatorial chemistry; protein dynamics and function; mechanistic aspects involved in cellular adhesion and transport in membrane and zeolite channels; and cutting-edge microscopes used to examine transport, motility, and reactivity in cells.

Chemical Physics

The research interests of the members of the Chemical Physics Thematic Research Group are diverse, with groups focusing on high-end laser and NMR spectroscopies, kinetics and modelling of atmospheric chemical reactions, experimental and theoretical biophysical chemistry, polymers at interfaces, and statistical and quantum mechanics. In the field of biophysical chemistry, single molecule spectroscopy is being used to probe enzyme function as well as DNA recombination and repair. Our recent advances in image correlation spectroscopic techniques now allow researchers to precisely follow the macromolecular dynamics in living cells. In a similar vein, breakthrough ultra-fast electron diffraction experiments have opened the window to real-time observation of the making and breaking of chemical bonds. State-of-the-art multi-pulse femtosecond spectroscopy experiments are being applied to interesting and technologically important new materials such as photonic crystals and quantum dot superlattices. A molecular-level picture of polymer dynamics and structure at surfaces and interfaces is being developed through theoretical modelling, high-field solids NMR spectroscopy, electron microscopy, and other surface characterization methods. In the area of atmospheric chemistry, the chemical transformation of the atmosphere is being modelled both experimentally and theoretically to understand how these processes are currently affecting and driving climate change. Finally, we have basic theory projects relating to the experimental work just described, as well as in transport and structure in complex colloidal or zeolite systems, protein dynamics, and fundamental issues in quantum and statistical mechanics.

Materials Chemistry

The chemistry of materials is a rapidly evolving domain of research. Materials chemistry seeks to understand how composition, reactivity, and structure are related to function from a molecular perspective. The functionality of materials is expressed in a variety of areas including photonics, micro- and nano-electronics, biosystems, nanotechnology, drug delivery, catalysis, polymer science, molecular biology, and chemical and biological sensing. Activities of the Materials Chemistry Thematic Research Group are often broadly interdisciplinary. University-wide synergies among members of this group have led to the creation of the 不良研究所 Institute for Advanced Materials (MIAM) and the 不良研究所 Nanotools Facility. The latter comprises state-of-the-art micro/nanofabrication, atomic manipulation and high-performance computing facilities. MIAM and members of the Chemistry Department have established research that links the , the , the , and the . Synthetic approaches to new materials include research in dendrimers, polynucleic acid architectures, polymers that conduct electrons or light and biopolymers. Polymer and colloid science figure prominently as does research and applications of the chemistry and physical properties of nanostructures. There is significant activity in understanding directed molecular assembly at interfaces and in the application of sophisticated spectroscopic tools to explore them.

Synthesis/Catalysis

The Synthesis/Catalysis Research Activity Group is a collective to develop the state-of-art catalysts, synthetic methodologies, reaction mechanisms, and synthetic routes for organic chemicals, natural products, and materials. The following are the major research activities at 不良研究所: (1) Development of novel catalysts and catalytic reactions for highly efficient organic synthesis; Green Chemistry. This includes the study and discovery of novel transition-metal catalysts, biological catalysts, nano- and dendrimer-based catalysts for synthetic purposes; new chemical reactivity such as C-H activation, asymmetric catalysis and theory, multi-component reactions and combinatorial chemistry; innovative chemistry in alternative solvents such as water, sub-critical water, ionic liquids, and liquid CO2; photocatalytic reactions, reaction mechanisms, and physical organic chemistry; and computational chemistry. (2) Synthesis of biological compounds, organic materials, and natural products. Focus areas are total synthesis of natural products, synthesis of DNA and RNA analogues; synthesis of antiviral and anticancer nucleoside analogues, synthesis of amino acid and peptides; synthesis and study of carbohydrate derivatives; design, synthesis, and study of speciality organic chemical and materials.