The first Innovative Ideas Competition launched in Fall 2017 and 85 people submitted Letters of Intent (LOI). Of these, 22 were invited to submit a full application for review by a panel of 25 national and international reviewers outside of 不良研究所. Twelve projects were awarded funding from these 22 applications.
Funded projects
| HBHL Research Theme 3 |
|---|
| Understanding resilience and disease by using language and the brain to predict individual outcomes |
| Targeted plasticity for recovery from cortical visual impairment |
Funded project聽summaries
Deep learning approaches to tackle neuroimaging challenges
The goal of this project is to develop deep learning architectures for analyzing large-scale neuroimaging data, specifically the BigBrain 3D dataset, which is the result of a long-term collaboration between the Evans laboratory at 不良研究所 and the laboratory of Katrin Amunts in J眉lich, Germany. The BigBrain 3D dataset is the most detailed 3D digital atlas of the human brain available.
HBHL Research Theme:听1
Principal Investigator:听Alan Evans
颁辞-笔滨:听Yoshua Bengio (Universit茅 de Montr茅al)
颁辞濒濒补产辞谤补迟辞谤蝉:听Konrad Wagstyl (University of Cambridge), Adriana Romero (Universit茅 de Montr茅al), Joseph Cohen (Universit茅 de Montr茅al), Katrin Amunts (Forschungszentrum J眉lich), Timo Dickscheid (Forschungszentrum J眉lich)
Funding Received (over 2 years):听$161,500
Developing vascularized brain organoids on chips for high-throughput screening
Human induced pluripotent stem cells (hiPSC) can be differentiated into neural organoids (mini-brains). To improve organoid reproducibility, the team is testing novel stable polymer biomaterials. They are developing a 3D microfluidic chip to support organoid vascularization to increase organoid size and better model the multicellular complexity of the human brain. By improving neural organoid technology, researchers will be able to better model human neurodegenerative disease and develop new treatments.
HBHL Research Theme: 1
Principal Investigator: Timothy Kennedy
Co-PIs: Christopher Barrett (不良研究所), David Juncker (不良研究所)
Collaborators: Edward Fon (不良研究所), Thomas Durcan (不良研究所), Tanja Kuhlmann (Universit盲tsklinikum M眉nster), Amir Shmuel (不良研究所), Louis Collins (不良研究所), Kevin Petrecca (不良研究所), Edith Hamel (不良研究所)
Funding Received (over 2 years): $170,000
Estimating spatially resolved microstructural features of the brain based on quantitative MRI
The aim of this study is to map microstructural features of the brain, such as relative myelin content, cell density and fibre bundle orientation, using in-vivo quantitative MRI. This project will create a framework for comparing MRI-based estimates of brain microstructure to histological measurements, as well as improved estimation of relative myelin content, cell density and fibre bundle orientation from multi-modal structural and diffusion MRI.
HBHL Research Theme: 1
Principal Investigator: Amir Schmuel
Co-PIs: Ravi Menon (Western University), David Rudko (不良研究所)
Collaborators: Sergey Plis (University of New Mexico), Corey Baron (Western University). Louis Collins (不良研究所)
Funding Received (over 2 years): $170,000
High-complexity statistical modeling via optimal transportation
This project developed new metrics for evaluating confidence/uncertainty measures for classification by Deep Neural Networks, which are useful for making accurate, model-free predictions based on massive datasets. Based on optimal transportation theory, the team created theoretical results and computational procedures. The goal is to facilitate the holistic and integrated analysis of various types of health data.
HBHL Research Theme: 1
Principal Investigator: David Stephens
Co-PIs: Adam Oberman (不良研究所)
Collaborators: Esteban Tabak (Courant Institute)
Funding Received (over 2 years): $147,900
Marmoset Magnetic Resonance Imaging platform
The goal of this proposal was to develop a platform for marmoset magnetic resonance imaging (MRI) on the human 3 Tesla scanner at the McConnell Brain Imaging Centre. MRI techniques were developed for in vivo anesthetized marmoset imaging. To create a multi-modal marmoset brain atlas, the team optimised several acquisition protocols and image analysis pipelines.
HBHL Research Theme: 1
Principal Investigator: Christine Tardif
Co-PIs: David Rudko (不良研究所), Philippe Huot (不良研究所), Louis Collins (不良研究所)
Collaborators: Stephen Frey (Rogue Research Inc.), Stephen Nuara (不良研究所), Ilana Leppert (不良研究所), Rick Hoge (不良研究所), Michael Petrides (不良研究所), Julien Doyon (不良研究所), Abbas Sadikot (不良研究所), Edward Fon (不良研究所)
Funding Received (over 2 years): $169,997
Brain hemodynamic signals as a dynamic biomarker of dementia initiation, progression and treatment
It is unclear whether brain imaging techniques, such as functional MRI, can detect disease onset, progression and response to therapy in pathologies such as Alzheimer's disease (AD) and vascular dementia. To test these hypotheses, this project employs animal models of Alzheimer's disease and vascular dementia, as well as a technique similar to functional MRI. The project's findings should provide a firm conclusion on the feasibility of using brain imaging data in the diagnosis and treatment of these two types of dementia.
HBHL Research Theme: 2
Principal Investigator:听Edith Hamel
颁辞-笔滨:听Fr茅d茅ric Lesage (Universit茅 de Montr茅al)
颁辞濒濒补产辞谤补迟辞谤蝉:听Christophe Grova (Concordia)
Funding Received (over 2 years):听$170,000
In vivo cholinergic markers of preclinical Alzheimer鈥檚 disease progression
This project seeks to determine whether the dysfunction of specific nerve cells following degeneration in the front and bottom of the brain precedes and predicts the spread of Alzheimer's disease pathology across the cerebrum's surface. The project team is collecting neuroimaging markers of brain structure and function, cholinergic system function and cognition in a group of asymptomatic participants who are at high risk of developing Alzheimer's. The project's goal is to stimulate new initiatives towards early diagnosis of prodromal syndromes using multimodal imaging.
HBHL Research Theme: 2
Principal Investigator: R. Nathan Spreng
Co-PIs: John Breitner (不良研究所), Sylvia Villeneuve (不良研究所), Judes Poirier (不良研究所), Jean-Paul Soucy (不良研究所), Pedro Rosa-Neto (不良研究所), Pierre Bellec (Universit茅 de Montr茅al)
Collaborators: Taylor Schmitz (不良研究所), Marc-Andr茅 B茅dard (UQAM)
Funding Received (over 2 years): $169,952
Measuring protein turnover in organoid and animal models of Parkinson鈥檚 disease
Several studies suggest that Parkinson's disease (PD) is caused by damage to mitochondria. Because PD neurons are especially vulnerable to mitochondrial damage, PD develops when they are not repaired. Notably, a protein called Parkin, which causes familial PD when mutated, functions by inducing the degradation of damaged mitochondria. This project team is the first to measure the rate of mitochondrial degradation in brain-like organoids derived from human stem cells with a Parkin deletion. This tool will be used to test new drugs that restore mitochondrial repair.
HBHL Research Theme: 2
Principal Investigator: Jean-Francois Trempe
Collaborators: Thomas Durcan (不良研究所), Edward Fon (不良研究所)
Funding Received (over 2 years): $85,000
Understanding resilience and disease by using language and the brain to predict individual outcomes
The use of computerised algorithms to analyse subtle speech variation can predict disease progression. This project team will create computerised algorithms to analyse speech and detect signs of cognitive ageing and disease risk. The project's outcomes could pave the way for the development of widely accessible and low-cost diagnostic tools for assessing disease risk.
HBHL Research Theme:听3
Principal Investigator:听Denise Klein
Co-PIs:听Michael Petrides (不良研究所), Shari Baum (不良研究所)
颁辞濒濒补产辞谤补迟辞谤蝉:听Morgan Sonderegger (不良研究所), Natalie Phillips (Concordia), Edward Fon (不良研究所)
Funding Received (over 2 years):听$170,000
Targeted plasticity for recovery from cortical visual impairment
Following stroke or traumatic brain injury, many patients experience cortical visual impairment (CVI), which manifests as a large blind spot in their visual field. According to some studies, CVI patients can be trained to respond to simple stimuli in their blind fields. The goal of this project is to design and test new training protocols based on the expertise of PI Chritopher Pack's lab in the visual cortex.
HBHL Research Theme: 3
Principal Investigator: Christopher Pack
Co-PIs: 脡tienne de Villers Sidani (不良研究所)
Collaborators: C茅line Odier (Universit茅 de Montr茅al), Rosa Sourial (MUHC), Marie-Jos茅e Gagnon (H么pital de r茅adaptation Villa Medica), Robert Gordon (The Article 19 Group, Inc.)
Funding Received (over 2 years): $146,356
A personalized approach to depression care: Discovering adaptive treatment strategies
Tailoring treatment to patients with depression requires evidence-based strategies. The goal of this study is to use electronic health records to discover adaptive treatment strategies that tailor sequential treatment decisions to patient characteristics such as symptom patterns, co-occurring conditions and response to previous treatments.
HBHL Research Theme:听4
Principal Investigator:听Erica Moodie
Co-PIs:听Samy Suissa (不良研究所), Christel Renoux (不良研究所)
颁辞濒濒补产辞谤补迟辞谤蝉:听Susan Shortreed (Kaiser Permanente), Gregory Simon (Kaiser Permanente)
Funding Received (over 2 years):听$131,695听
When gender matters: Differential effects of prenatal adversity on the development of ADHD and related neurocognitive deficits
This study looks at how sex-dimorphism, prenatal programming, maternal mood, parenting and genetic risk for Attention Deficit Hyperactivity Disorder (ADHD) interact and manifest themselves across several cohorts from childhood to early adulthood. The project examines the severity of a multi-level ADHD construct to assess the multiple modal differences in boys and girls.
HBHL Research Theme:听4
Principal Investigator: Ashley Wazana
Co-PIs: J. Bruce Morton (Western University), Tim Oberlander (University of British Columbia), Celia Greenwood (不良研究所)
Collaborators: Michael Meaney (不良研究所), James Kennedy (University of聽Toronto), Jonathan Evans (University of Bristol), Henning Tiemeier (Erasmus)
Funding Received (over 2 years): $169,575
